Trailer: ‘Big Mouth’ returns December 4 new guest stars and a focus on teen anxiety
The show addresses the issue of Jenny Slate voicing a Black character in early episodes
Netflix’s Emmy-nominated animated hit Big Mouth is set to return December 4 for its fourth season.
This season focuses on anxiety; the anxiety of growing up, of figuring out who you are, discovering yourself, accepting yourself. The season starts at summer camp before our gang heads to 8th grade. Maria Bamford descends as Tito the Mosquito, the anxiety ridden insect who targets all our favorite kids. As the season progresses, we meet Zach Galifianakis’ Gratitoad, who is there to help our crew cope with their anxiety and not let it completely own them.
Big Mouth continues to explore human sexuality and everything around it, including racial and sexual identity, love in all its forms, and having “The Hugest Period Ever.”
Additional guest stars include: Seth Rogen, Josie Totah, Lena Waithe, Quinta Brunson, John Oliver, Sterling K. Brown, Paul Giamatti, Maya Erskine and Anna Konkle. As previously announced, Ayo Edebiri has been cast as Missy, replacing Slate, and will first be introduced during the penultimate episode as her character continues to evolve. She will continue to voice Missy in the final episode and for future seasons.
- Alliance of Women Film Journalists (AWFJ): ‘One Battle After Another,’ ‘Hamnet’ Lead - December 22, 2025
- North Texas Film Critics Association (NTFCA) Nominations - December 22, 2025
- Kansas City Film Critics Circle (KCFCC) Awards: ‘One Battle After Another’ Named Best Film - December 21, 2025



Writer/Director Charlie Polinger Tackles Teenage Boy Body Horror in his Debut Feature ‘The Plague’ [VIDEO INTERVIEW]
‘The Testament of Ann Lee’ Review: Amanda Seyfried is Mother (Ann) in Mona Fastvold’s Miraculous Musical Drama [A]
With ‘Song Sung Blue,’ Craig Brewer Pays Tribute to Kate Hudson and Hugh Jackman, Joy Amongst Sadness, and the Creation of Art [VIDEO INTERVIEW]
Director Watch Podcast Ep. 131 – ‘High Life’ (Claire Denis, 2019)